October 1 - 4, 2026   Radisson Blu Aqua Hotel, Chicago

Shaping the Future of Breast Cancer Treatment

Multidisciplinary perspectives on emerging therapies and evolving standards of care

For nearly three decades, the Lynn Sage Breast Cancer Symposium has convened leaders across medical, surgical, and radiation oncology to explore the full spectrum of breast cancer care—from early detection and localized disease to advanced and metastatic treatment. With a longstanding reputation for practice‑changing insights, the symposium highlights cutting‑edge science, newly established therapies, and critical clinical controversies shaping contemporary care.

This page explores the Lynn Sage program in greater depth and why clinicians across breast cancer disciplines continue to choose it. Read on for more detail.


Be at the Forefront of Breast Cancer Care in 2026

Clinical topics and emerging therapies in breast cancer care

The 2026 agenda focuses on what's new, what's rapidly evolving, and where expert judgment matters most - spanning imaging, pathology, adjuvant and advanced systemic therapy, local management, risk, and survivorship.

New to Lynn Sage in 2026

  • AI in Breast Imaging - AI is here. What it truly means for detection, screening, and real-world clinical decision-making.
  • WHO Classification of Breast Tumors (6th Edition) and Practical Pathology Updates - What changed, why it matters, and how it affects diagnosis and management today.
  • Molecular Progression as a Treatment Trigger - Should molecular progression, not just clinical progression, change how and when we treat?
  • Axillary Management in 2026 - Re-examining the role of surgery and radiation: when can we eliminate axillary intervention, and when does it still matter?
  • Antibody-Drug Conjugates (ADCs) in Hormone-Refractory Disease - Practical guidance on use today, sequencing, and what's coming next.

Rapidly Evolving Core Topics-Revisited with New Evidence

  • Oral Selective Estrogen Receptor Degraders (SERDs) in Metastatic Breast Cancer - Where the evidence stands now in a fast-changing landscape.
  • Emerging Approaches in Risk Assessment & Management - Where evidence meets real-world constraints in screening and prevention.
  • De-Escalation and the Optimization of Local & Systemic Therapy - Updates in adjuvant and locoregional treatment, balancing efficacy with long-term quality of life across surgery, radiation, and subtype-specific systemic therapy.
  • Survivorship Care & Treatment-Related Morbidity - Hormone replacement therapy, diet, exercise, and long-term health across the continuum of care.

Clinical Controversies & Case-Based Decision-Making

Applying evidence when answers aren't clear-cut.

A core feature of the Lynn Sage meeting, these sessions focus on clinical reasoning, multidisciplinary perspectives, and decision-making in areas where uncertainty remains. As always, this year's program includes:

  • Unusual Cases Panel Rare and uncommon breast cancer cases that challenge standard assumptions, highlighting how experts reason through limited data, atypical presentations, and diagnostic uncertainty.
  • Multidisciplinary Case Management Panel Complex real-world cases requiring coordination across surgery, medical oncology, radiation oncology, pathology, and imaging- illustrating how teams align on care when multiple reasonable options exist.
  • Lectures Addressing Ongoing Clinical Controversies Expert lectures on debated topics including DCIS, brain metastases, hormone replacement therapy, and locoregional treatment best practices, highlighting how evolving evidence, uncertainty, and real-world constraints shape clinical decision-making.

Together, these sessions reinforce the meeting's emphasis on thoughtful clinical judgment and practical decision-making across the continuum of breast cancer care.

See the full agenda in detail here


Distinguished Faculty

A nationally recognized faculty of 30+ breast cancer leaders and investigators from premier institutions— including Memorial Sloan Kettering, Dana‑Farber, MD Anderson, Mayo Clinic, UCSF, and Northwestern— delivers practical insight into how novel science is reshaping clinical practice. View the faculty list

Advancing Clinical Practice

Focused on the most current evidence, next-generation therapies, and unresolved clinical questions, the symposium delivers practical education that clinicians can apply immediately to patient care at every level.

Multidisciplinary Audience

The symposium attracts a highly engaged, multidisciplinary audience of practicing clinicians, including medical, surgical, and radiation oncologists, advanced practice providers, nurses, pharmacists, and researchers. With strong national and regional representation and a high rate of repeat attendance, Lynn Sage offers meaningful access to clinicians who influence breast cancer treatment decisions from early detection through metastatic disease.

Networking & Connection

Designed to foster conversation, collaboration, and connection among faculty and attendees

  • Built‑in networking during breaks, meals, and receptions
  • Centralized gathering space that encourages informal discussion
  • Multiple days together, allowing relationships and dialogue to develop organically

Overview

Learn more about the symposium by watching this video:

© 2026 Robert H. Lurie Comprehensive Cancer Center