Improving
the Therapeutic Index of Taxane - Based Therapy
OBJECTIVES
• Describe the clinical
activity and limitations of solvent-based taxane therapy (paclitaxel,
docetaxel) in patients with metastatic breast cancer
• Describe the rationale for developing a solvent-free, nanoparticle-sized,
albumin-based drug delivery system
• Describe the results from clinical trials
evaluating the efficacy and tolerability of nanoparticle albumin
bound paclitaxel in patients with metastatic breast cancer
• Describe other novel, non-solvent based
taxanes in clinical development
FACULTY
William Gradishar, MD Robert H. Lurie Comprehensive
Cancer Center of Northwestern University
Hope Rugo, MD UCSF Comprehensive Cancer Center
Moderator William Gradishar, MD Robert H. Lurie Comprehensive
Cancer Center of Northwestern University